अणु और जैव गतिविधियां (9) S.No Title Inventors Patent No. Summary 1. 520NF2002 Use of phyllocladane diterpenoids for plant frowth promotion and alleviatin of growth retardant allelochemicals AK Singh, GD Bagchi, Sarita Singh, PD Dwivedi, AK Gupta, SPS Khanuja Australia/2002348820/14.2.2007 US/6673749/6.1.2004 The invention provides plant growth-promoting activities of active plant constituent calliterpenone and its derivatives belonging to the group phyllocladane diterpenoids. These phytochemicals and derivatives exhibit remarkable growth promoting activities on plant roots, shoots and promote seed germination both in mono and dicotyledonous plants. These phytomolecule possess antagonistic activity against allelochemicals of plant growth retardant nature and hence can be used to alleviate their detrimental effects. 2. 526NF2001 Use of the root extract of Vetiveria zizanioides in curing fluoroquinolone and multi drug resistant bacterial infections SPS Khanuja, Suchi Srivastava, TRS Kumar, MM Gupta, AK Tripathi, Monika Singh, JR Bahl, RK Lal, MP Darokar, AK Shasany, Sushil Kumar US/6676974/13.1.2004 India/218190/31.3.2008 The present invention relates to a hexane bioactive fraction obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals. It also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract. 3. 209NF2003 A new nitrile glycoside useful as a bioenhancer of drugs and nutrients and the process of its isolation from Moringa oleifera SPS Khanuja, JS Arya, TRS Kumar, D Saikia, HS Kaur, Monika Singh, SC Gupta, AK Shasany, MP Darokar, SK Srivastava, MM Gupta, SC Verma, Anirban Pal US/6858588/22.2.2005 India/234974/23.6.2009 The invention relates to a novel nitrile glycoside named NIAZIRIDIN and the analogues and derivatives thereof by bioactivity-guided fractionation from the pods of Moringa oleifera in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (-) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore, niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy. 4. 508NF2003 A novel plant growth promoting naphthophenone derivative from gallic acid AS Negi, MP Darokar, SPS Khanuja, SK Chattopadhyay, Ankur Garg, Togarrati Padmapriya, Sachin Srivastava, AK Shasany, AK Bhattacharya, India/250039/30.11.2001 This invention provides a plant growth regulatory activity of a new biologically active synthetic molecule Methanone- (3', 4', 5'-trimethoxy) phenyl, 1-naphthyl, 2-O-4'-ethyl but-2'-enoate. More particularly, the invention relates to the potent plant growth promoting activity of a gallic acid derivative having the structural formulae (1) and molecular formulae C26H26O7. This invention also provides a novel process for preparation of a said molecule from a naturally occurring compound and testing it for growth regulating activity using Bacopa test system developed at CIMAP (Khanuja et al 2001). 5. 133NF2011 Benzylidene indanones and processes for preparation and use thereof AS Negi, AP Prakasham, AK Saxena, S Luqman, D Chanda, Tandeep Kaur, Atul Gupta US/8633242/21.1.2014 India/291668/12.1.2018 The invention relates to the potent anticancer and tubulin polymerization inhibition activity of new benzylidene indanones synthesized from gallic acid against several human cancer cell lines. The invention also provides a new process for the preparation of the said molecules and testing these for in vitro cytotoxic activity against various human cancer cell lines using Sulphorhodamine B Assay. Compounds were evaluated for acute oral activity in Swiss albino mice and were found to be safe up to 300mg/kg body weight. 6. 144NF2008 Novel antipsychotic activity in the leaf extracts of Rauwolfia tetraphylla and their useful herbal formulations SK Srivastava, AK Agarwal, SC Singh, VK Khanna, Janardan Singh, Chandeshwar Nath, MM Gupta, Shikha Gupta, RK Verma, Anirban Pal, DU Bawankule, D Saikia, AK Gupta, Anupam Maurya, SPS Khanuja Australia/2010231489/8.1.2015 US/9018226/28.4.2015 The invention relates to novel antipsychotic activity in the leaf extracts of Rauwolfia tetraphylla and their useful herbal formulations for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and serotonergic (5HT2A) receptors for antipsychotic activity. The invention also provide a process for obtaining antipsychotic extracts from the leaves of Rauwolfia tetraphylla, which are non toxic and devoid of extra pyramidal side effects. 7. 012NF2010 -Yohimbine and its derivatives as antipsychotic agents and process of their preparation SK Srivastava, VK Khanna, Shikha Gupta, AK Agarwal, Chandishwar Nath, MM Gupta, R Kishore Verma India/281936/29.3.2017 The present invention relates to the development of a virtual screening model for predicting antipsychotic activity using quantitative structure activity relationship (QSAR), molecular docking, oral bioavailability, ADME and Toxicity studies. QSAR model showed activity-descriptors relationship correlating measure (r2) 0.87 (87%) and predictive accuracy of 81% (rCV2=0.81). The present invention specifically showed strong binding affinity of the untested (unknown) novel compounds against anti-psychotic targets viz., Dopamine D2 and Serotonin (5HT2A) receptors through molecular docking approach. The present invention further showed compliance of Lipinski's rule of five for oral bioavailability and toxicity risk assessment for all the active Yohimbine derivatives. 8. 001NF2015 2-Benzyl-indanone compounds as anticancer agent and a process for preparation thereof AS Negi, Astha Singh, Suib Luqman, D Chanda, Dilip Manikrao Mondhe, AK Saxena, Kaneez Fatima, Arjun singh France, GB/3322687/26.2.2020 India/356367/21.1.2021 The anticancer activity of gallic acid derivative has been invented, in order to obtain new potent and cost effective molecule using in vitro cytotoxicity assay. The compound also exhibited tubulin polymerisation inhibition. 2-(3′,4′-methylenedioxybenzyl)-3-(3″,4″,5″-trimethoxyphenyl)-indanone-1 (1), possessing molecular formulae as C29H30O9 was synthesized from gallic acid, exhibits potent in-vivo anticancer activity. Compound 1 was evaluated for acute oral activity in Swiss albino mice and it was found to be well tolerated by the experimental animals up to 300mg/kg body weight. 9. 106NF2016 A novel composite catalyst system for eco-friendly synthesis of menthol from citronellal rich essential oil Anju Yadav, AK Shasany 18.1.2021 The present invention relates to an eco-friendly, efficient and economical process for the synthesis of menthol from citronellal rich essential oil. The complete synthesis has been divided into two steps, (i) synthesis of isopulegol from citronellal, (ii) synthesis of menthol from isopulegol. The present invention further relates to the synthesis of novel catalysts -zeolite-boric acid-aluminium chloride or -zeolite-boric acid-aluminium chloride or -Na-zeolite-boric acid-aluminium chloride or Ag-exchanged zeolite-boric acid-aluminium chloride or -zeolite-boric acid-tin(II)chloride or -zeolite-boric acid-tin(II)chloride or -Na-zeolite-boric acid-tin(II)chloride or Ag-exchanged zeolite-boric acid-tin(II)chloride for synthesis of isopulegol from citronellal. Similarly, synthesis of 1% palladium-AC (activated carbon) or 1% ruthenium-AC or 1% palladium-graphene or 1% ruthenium-graphene are effective for conversion of isopulegol to menthol under 10 to 15 psi hydrogen pressure. This reduction step (second step) is equally effective without external hydrogen pressure by adding the catalytic amounts of sodium borohydride or sodium aluminium hydride or lithium aluminium hydride or calcium hydride or sodium hydride. Finally, the enriched L-menthol is obtained through esterification of menthol enantiomers to menthyl acetate or menthyl benzoate followed by hydrolysis. Formulations and compositions (3) S.No Title Inventors Patent No. Summary 1. 226NF2005 Synergistic anti - malarial formulation GP Dutta, DC Jain, RS Bhakuni, S. Saxena, Sangeeta Dhawan, SPS Khanuja, Sushil Kumar, Renu Bajpai, Aseem Umesh, Nuzhhat Kama, AK Dwivedi, Satyavan Singh India/211247/23.10.2007 The invention relates to a synergistic formulation comprising pharmaceutically effective amount of alpha/beta. arteether and a neutralized refined vegetable oil suitable for administration by rectal route. The invention also provides the method for the treatment of cerebral and comatose malaria and process for the preparation of the said formulation. 2. 235NF2002 Composition and process for preparing herbal disinfectants and their use SPS Khanuja, Suchi Srivastava, TRS Kumar, MM Gupta, AK Tripathi, Monika Singh, JR Bahl, RK Lal, MP Darokar, AK Shasany, Sushil Kumar India/233624/31.3.2009 The invention relates to development of the disinfectants that are non-toxic, biosafe and in addition give pleasant odour. The disinfectants already available in the market contain harmful chemicals such as formaldehyde, ethane dialdehyde, n-propanol, benzalkonium chloride, and phenol. The present invention relates to disinfectant compositions for cleaning the skin of humans and for cleaning surfaces such as floors. The compositions are homogeneous, clear and also useful as disinfectant. The invention also provides as process for the preparation of the cleaning composition. The compositions are prepared by mixing the components in a particular well-defined order to obtain clear, transparent solutions effective against pathogenic bacteria and fungi. 3. 265NF2003 Improved anti-dermatophytic preparation and use thereof SPS Khanuja, Pushplata Chaturvedi, AK Singh, AK Shasany, VK Agarwal, VK Gupta, SC Gupta, AK Tripathi, Anirban Pal, Dharmendra Saikia, MP Darokar, KK Agarwal, RP Bansal India/234314/20.5.2009 The invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungi. More particularly, invention relates to the synergistic enhancement of activity of a combination by methyl acetate or geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations. नई बेहतर प्रक्रिया (9) S.No Title Inventors Patent No. Summary 1. A process for isolation of bioactive hexane fraction from Vetiveria zizanioides pharmaceutical composition prepared therefrom SPS Khanuja, Suchi Srivastava, TRS Kumar, MM Gupta, AK Tripathi, Monika Singh, JR Bahl, RK Lal, MP Darokar, AK Shasany, Sushil Kumar India/231854/12.3.2009 The present invention relates to a hexane bioactive fraction obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals. It also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract. 2. 228NF2011 A process for chemical conversion of isolated cellulose from aromatic spent biomass to hydroxy methyl furfural PK Rout, AD Nannaware, Ram Rajasekharan US/9199956/1.12.2015 India/326942/6.12.2019 The invention relates to the development of green process for the preparation of hydroxymethyl furfural (HMF) from cellulose isolated from spent aromatic biomass. HMF is a key intermediate substance useful as substitute of petro chemicals. As cellulose is the major constituent (40-50%) of the spent aromatic biomass (hemicellulose, 25-30% and lignin 15-20%) it is being used for synthesis of HMF. The synthesis of HMF from isolated cellulose is an economical process and is completely environment-friendly which describes the development of sustainable, integrated and holistic strategy for utilizing the waste aromatic biomass to produce various valuable bio-chemicals. 3. 114NF2005 Improved process for the isolation of 'Calliterpenone' a natural plant growth promoting phyllocladane ditterpenoid from Genus callicarpa AK Singh, SPS Khanuja, Sudeep Tandon, Alok Kalra, D Sahoo, AP Kahol, MM Gupta, RK Verma, AK Kukreja, Mansoor Alam, GD Bagchi, RP Bansal, MP Darokar, AK Gupta Australia/2006340617/6.3.2014 US/7527814/5.5.2009 South Africa/2008/8011/26.8.2009 The invention provides a simple method for isolation of calliterpenone a phyllocladane di-terpenoid with the plant growth regulating properties, from plant genus Callicarpa. 4. 418NF2003 Process for isolation of withaferin-A from plant materials and products therefrom RS Sangwan, ND Chaurasiya, LN Misra, Payare Lal, GC Uniyal, NS Sangwan, Avdhesh K Srivastava, Krishan Avtar Suri, Ghulam Nabi Qazi, Rakesh Tuli US/7108870/19.9.2006 India/244612/13.12.2010 An improved process of analytical and quantitative isolation of withaferin-A from Withania somnifera and other plants has been developed in which extraction solvent system consisting of a defined admixture of water and alcohol (preferably 60% alcohol and 40% water) for the dry plant material and from 60% to 80% alcohol for fresh plant material. The invented extract composition lead to better / improved yields and accurate quantitative estimations of withaferin A existent in plants or in material. The new process is valuable and advantageous for standardization of botanicals and metabolomic characterization of plants. 5. 506NF2002 An improved process for the production of brevifoliol from Taxus wallichiana SK Chattopadhyay, Sachin Srivastava, AS Negi, TRS Kumar, Ankur Garg, SPS Khanuja India/235045/24.6.2009 The invention provides an economic process for large scale production of an anticancer taxoid “brevifoliol” from plants belonging to the genus Taxus. 6. 453NF2002 Single pot conversion of artemisinin into artesunic acid RS Bhakuni, AP Kahol, Tarun Singh, SPS Khanuja India/234269/14.5.2009 The present invention provides a single pot process for the preparation of artesunic acid from artemisinin involving reduction followed by etherification of the reduced product at room temperature. The conversion of artemisinin into crude artesunic acid followed by workup and purification to yield pure product takes 6-10 hours as compared to previously reported methods (about 24-72 hours) and thus is less time consuming. The yield of final product in the present invention i.e. pure artesunic acid it upto 96% (w/w). 7. 318NF2002 Single pot conversion of artemisinin into arteether RS Bhakuni, Amit Tiwari, Tarun Singh, SPS Khanuja India/234267/14.5.2009 The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst. 8. 230NF2001 Single pot conversion of artemisinin into artemether RS Bhakuni, Tarun Singh, AP Kahol, Amit Tiwari, Sudeept Tandon, SPS Khanuja India/224810/22.10.2008 The invention relates to an improved method for the preparation of artemether which is useful for the treatment of uncomplicated, severe complicated and multi-drug resistant malaria. The previous methods carry some disadvantages being less cost effective and more time consuming as compared to the present invention. Moreover, benzene, a carcinogenic solvent used in the previous methods is not acceptable according to the health standards. Further, all the previous methods require at least two separate steps to convert artemisinin into ethers i.e. reduction of the artemisinin into dihydroartemisinin in the first pot followed by isolation of dihydroartemisinin and then comes the second step of conversion of dihydroartemisinin into different ethers in the second pot. However, the present invention provides an efficient method for conversion of artemisinin into artemether in one pot in just 4 hours as compared to 24-72 hours in previous methods. 9. 269NF2014 An environment friendly process for isolation of lipids, cellulose, hemicellulose and lignin from the agricultural residues (biomasses) PK Rout, AD Nannaware, Om Prakash, Rajasekharan Ram US/10287527/14.5.2019 The present invention relates to an eco-friendly, efficient and economical process for the isolation of biopolymers such as lipids, cellulose, hemicellulose and lignin from agricultural residues. The present invention further relates to the preparation of new solvent systems such as imidazole-tosylic acid, imidazole-formic acid, imidazole-acetic acid, etc for isolation of lignin and aqueous solution of imidazole-alkali for isolation of hemicellulose. नई विधियाँ और तकनीकें (1) S.No Title Inventors Patent No. Summary 1. An efficient method for the faster multiplication of earthworms and production of superior quality vermicomposed from the distillation waste of industrial aromatic crops Alok Kalra, Sushil Kumar, Neetu Katiyar, JR Bahl, RP Bansal, HC Singh, Arun Prasad, Rakesh Panday, OP Dhawan, Alok Krishna, Ramesh Srivastava India/231000/28.2.2009 The invention related to a novel and efficient method for the faster production of superior quality vermicompost from the distillation wastes of aromatic/medicinal crops which have otherwise no economic value and are also not preferred by animals. No pre decomposition is required and compost developed by this method contains higher concentration of micro as well as macro nutrients. This method is significantly quicker and the process also results in the rapid multiplication of worms, thereby leading to production of vermicompost with higher nutrient status. पौधे की किस्में (8) S.No Title Inventors Patent No. Summary 1. 027NF2015 Vetiver plant named 'CIMAP-KHUSINOLIKA' HS Chauhan, HP Singh, C S Chanotiya, AK Shasany, UC Lavania, VKS Tomar, Alok Kalra, Ashok Kr Singh US/PP28388/12.9.2017 The present invention relates to the development of a novel, morphologically and genetically distinct khusinol rich essential oil producing clone of vetiver [Vetiveria zizaniodes (L.) Nash. syn. Chrysopogon zizanioides (L.) Roberty; family Poacaeae} named ‘CIMAP- Khusinolika’. The plant of this clone is characterized by spreading type clump canopy in the initial stage, white feathery stigma and capable of producing >1% (v/w) essential oil containing 45-50% Khusinol (v/v) obtained after hydro-distillation from fresh roots harvested from 06 month old plantations. This clone has unique ISSR profiles that serve as DNA-fingerprints. The clone was obtained through recurrent selection in polycrossed population generated from the bulk of wild collection, and can be propagated through vegetative slips (3 to 6 month old stem with few roots) for commercial plantation as a short duration crop. 2. 080NF2011 A novel autotetraploid clone 'CIMAP-KHUS 40' of vetiver (Vetiveria zizaniodes) useful for carbon sequestration and soil conservation UC Lavania, SK Rai, Lavania Seshu, Surochita Basu, Basant Kumar Dubey, Ram Ujagir US/PP26474/8.3.2016 The present invention relates to the development of a novel clone of Vetiver [Vetveria zizaniodes (L) Nash. syn. Chrysopogon zizaniodes (L.) Roberty; family Poaceae], named ‘CIMAP-KHUS 40’ characterized by somatic chromosome number 4x=40, larger stomata, fast growing deep penetrating roots, and seed infertility disabling its spread as a weed. This clone has unique ISSR and RAPD profiles that serve as DNA-fingerprints, and is developed from a unique diploid plant (2n=20). The invention document details all the pertinent data relating to this clone, its biological features and usefulness, and the method of its development. 3. 032NF2004 High artemisinin yielding plant genotype 'CIM-Arogya' Shilpi Paul, AK Shasany, AK Gupta, MP Darokar, MM Gupta, RK Verma, Govind Ram, Anuraddha Kumar, RK Lal, RP Bansal, AK Singh, RS Bhakuni, Sudeep Tandon US/7375260/20.5.2008 The invention is related to the development of a novel, distinct high herb and artemisinin yielding genotype of Artemisia annua obtained through systematic marker assisted breeding followed by selection of uniform population in a methodical way wherein the genotype is distinct, uniform and stably maintainable by continuous rouging of the off types in the population using DNA marker at early seedling stage from nursery itself and suitable for commercial cultivation. 4. 553NF2002 Early maturing, high yielding psyllium (Plantago ovata) variety ' Mayuri' with maturity marker RK Lal, Nilakshi Singh, HO Misra, JR Sharma, JR Bahl, AK Shasany, SPS Khanuja US/PP17505/20.3.2007 A new distinct early maturing, high seed and husk yielding variety of Psyllium (Plantago ovata) designated as var. ‘Mayuri’ has been developed with the distinct pigment marker of the panicles related to the maturity thereby indicating the right harvesting stage to prevent the seed shattering, a problem in Psyllium. This variety was developed by mutation breeding (gamma rays irradiation) and propagated by seeds for commercial cultivation 5. 552NF2002 Mint plant `Kushal` for late transplanting SPS Khanuja, AK Shasany, Usha Yadav, Sunita Dhawan, MP Darokar, JR Bahl, Soni Gupta, Sweta Pandey, AK Singh, RP Bansal, RK Lal, OP Dhawan, AA Naqvi, Alok Kalra, Alok Krishna, VKS Tomar, AK Singh US/PP16566/23.5.2006 A novel, distinct high yielding plant with rapid regeneration ability obtained through screening of the somaclones in a methodical way for fast regeneration in the tissue culture stage itself which was achieved by inventing the plant 'Kushal'. The plant yield higher herbage with corresponding high essential oil when evaluated with available superior varieties of mint in late planting condition during April when the fields are vacated after the harvest of Rabi crop like wheat, chickpea, coriander etc. 6. 520NF2002 Citral rich high yielding lemongrass plant `Nima` of Cymbopogon flexuosus RK Lal, HO Misra, JR Sharma, Nilakshi Singh, AK Shasany, AA Naqvi, JR Bahl, Arun Prasad, SPS Khanuja US/PP16712/27.6.2006 The new high yielding variety has very high content of citral in the essential oil. 7. 135NF2000 Mint plant Mentha spicata l. var.viridis christened as `Ganga` SPS Khanuja, Sushil Kumar, AK Shasany, SS Dhawan, MP Darokar, TK Tripathi, Sarita Satapathy, TRS Kumar, VK Gupta, Arvind K Tripathi, Soumya Awasthi, Veena Prajapati, AA Naqvi, KK Agarwal, JR Bahl, AK Singh, Ateeque Ahmed, RP Bansal, Alok Krishna, D Saikia US/PP16747/4.7.2006 A novel multi-utility mint plant christened as 'Ganga' of Mentha spicata L. var. viridis has been developed which has vigorous growth and produces essential oil which exhibit anti-insect and antimicrobial activities. The plant is highly useful for agrochemical and pharmaceutical purposes. 8. 449NF2003 A menthofuran rich unique chemotype plant Indus of Mentha piperita and harvest management method SPS Khanuja, NK Patra, AK Shasany, Birendra Kumar, Soni Gupta, RK Upadhyay, PP Togarratti, AK Singh, MP Darokar, VKS Tomar, JR Bahl, RK Lal US/PP16474/25.4.2006 A new and distinct mint plant of Mentha piperita 'CIM-Indus' has been developed which has high amount of menthofuran (22 to 30%) and high amount of pulegone (9.0 to 18%). Menthofuran is an important compound used in formulation of standardized essential oils.